Emerging role of microRNA-21 in cancer
نویسندگان
چکیده
منابع مشابه
Emerging role of microRNA-21 in cancer (Review)
MicroRNAs (miRs) are a class of single-stranded RNA molecules of 15-27 nucleotides in length that regulate gene expression at the post-translational level. miR-21 is one of the earliest identified cancer-promoting ‘oncomiRs’, targeting numerous tumor suppressor genes associated with proliferation, apoptosis and invasion. The regulation of miR-21 and its role in carcinogenesis have been extensiv...
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Pancreatic cancer (PC) is of the most highly aggressive malignant disease, and currently the fourth most frequent cause of cancer-related mortality in the United States [1]. It is expected that approximately 43,920 people are diagnosed with PC and about 37,390 will die of this disease in 2012 [1]. Despite recent therapeutic advancement, the median survival rate is less than 6 months, and 5-year...
متن کاملmicroRNA-21 and its emerging role in tumor progression in systemic malignancies.
modulatory effects of miR-21on the expression of Sprouty2 protein [8]. Increased PTEN expression is also seen. A similar impact is seen in gastric malignancies. miR-21 expression is typically accentuated in gastric carcinomas. This in turn results in decreased expression of Serpini1 [9], which augments tumor progression. Cancer cell migration is also enhanced at the same time. In addition, PTEN...
متن کاملMicroRNA-21 gene and cancer.
MicroRNAs (miRNAs) are a class of 18-27-nucleotides single-stranded RNA molecules that regulate gene expression at the post-transcriptional level. It has been demonstrated that miRNAs regulate a variety of physiological functions, including development, cell differentiation, proliferation, and apoptosis. There are growing evidence showed that miRNAs can affect the genesis and development of tum...
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MicroRNAs (miRNAs) are an evolutionarily conserved class of small, regulatory non-coding RNAs that negatively regulate protein coding gene and other non-coding transcripts expression. miRNAs have been established as master regulators of cellular processes, and they play a vital role in tumor initiation, progression and metastasis. Further, widespread deregulation of microRNAs have been reported...
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ژورنال
عنوان ژورنال: Biomedical Reports
سال: 2016
ISSN: 2049-9434,2049-9442
DOI: 10.3892/br.2016.747